Do you ever feel unusually sensitive to alcohol? Perhaps even small amounts leave you feeling nauseous, flushed, or with a racing heart. These reactions could indicate an inherited alcohol intolerance, often linked to a specific gene mutation, according to experts at the Cleveland Clinic. This mutation can affect the body's production of enzymes crucial for breaking down alcohol and its byproducts.
Unmasking Alcohol Intolerance Through Genetic Testing
At-home DNA tests can now identify these mutations in the ADH and ALDH genes, which play a vital role in alcohol metabolism. For around $150, these tests involve a simple cheek swab, with results typically available within two weeks. Companies like Genex Diagnostics promote these kits as a way to understand individual responses to alcohol and potential health risks.
Image: A woman experiencing discomfort after consuming wine. (iStock)
Dr. Frances Lee, a hepatologist at Mount Sinai Health Systems, explains that the ADH1B and ADH1C genes break down ethanol into acetaldehyde, a toxic compound. The ALDH2 gene then converts acetaldehyde into acetic acid. Variations in ALDH2 can slow this process, leading to acetaldehyde buildup and unpleasant symptoms.
Image: A man experiencing a headache. (iStock)
Navigating the Nuances of Genetic Testing
While these tests can offer insights, experts caution against over-interpreting the results. A negative result doesn't necessarily mean one can drink excessively without consequences. Dr. Fred Davis, associate chair of emergency medicine at Northwell Health, emphasizes that the test identifies susceptibility, not immunity to alcohol's effects.
Image: Using a mouth swab for DNA testing. (iStock)
Prioritizing Responsible Alcohol Consumption
Registered dietitian Makenzi Mollitor offers guidance for those who choose to drink. She recommends focusing on quality over quantity, opting for lower-sugar options like orange wine or naturally fermented wines rich in polyphenols. She also advises adhering to recommended daily limits: one drink for women and two for men.
Image: A representation of a broken DNA strand. (iStock)
Image: A man consuming an alcoholic beverage. (iStock)
Dr. Lee highlights the significant impact of alcohol on liver health, as alcohol-related liver disease is a leading cause of liver transplants in the US. He encourages anyone concerned about their alcohol consumption to consult a liver specialist.
